It is actually tough to figure out what constitutes a regular harmful or lethal dose. Having said that, the lethal oral dose of codeine within an Grownup is noted to become in the choice of 0.
Most MAO inhibitors must also not be taken for 2 months in advance of cure using this medication. Check with your doctor when to start or quit using this medication.
Check out your local drug retail store and clinics for choose-again spots. It's also possible to Examine the DEA web site for destinations. Here is the connection for the FDA Harmless disposal of medicines Site:
As a result of hazard of respiratory despair, keep away from the use of opioid antitussives, including Promethazine HCl and Codeine Phosphate Oral Option in sufferers with compromised respiratory operate, patients vulnerable to respiratory failure, As well as in elderly, cachectic, or debilitated individuals.
Promethazine should be made use of with warning in individuals with bone marrow despair. Leukopenia and agranulocytosis happen to be reported, commonly when promethazine HCl has been Utilized in association with other regarded marrow-toxic brokers.
Make contact with community state Experienced licensing board or point out controlled substances authority for info on how to avoid and detect abuse or diversion of this merchandise.
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Codeine Within an embryofetal enhancement study in pregnant rats dosed throughout the period of organogenesis, codeine increased resorptions and reduced fetal weights at a dose close to 25 times the MRHD (with a mg/m2 foundation using a maternal oral dose of 120 mg/kg/day); on the other hand, these consequences happened while in the existence of maternal toxicity.
Narcotic analgesics, like codeine, exert their primary consequences to the central nervous system and gastrointestinal tract. The analgesic results of codeine are because of its central motion; having said that, the precise sites of motion have not been established, and the mechanisms concerned appear to be fairly intricate.
Tend not to rise up or sit up quickly, especially if you will be an more mature affected individual. This minimizes the chance of dizzy or fainting spells. Alcoholic beverages could interfere Using the effect of the medication. Keep away from alcoholic beverages.
This is very critical for elderly people, who can be far more delicate to the results of agony Promethazine codeine syrup medicines. If far too much of the medicine is taken for a long period, it may come to be habit-forming (causing psychological or physical dependence) or bring about an overdose.
Codeine has become described to show no proof of carcinogenicity or mutagenicity in many different take a look at systems, such as the micronucleus and sperm abnormality assays as well as the Salmonella assay. Promethazine was nonmutagenic while in the Salmonella test method of Ames.
Opioid analgesics and antitussives, which include codeine, one of several active elements in Promethazine HCl and Codeine Phosphate Oral Alternative, shouldn't be used in people with acute febrile sickness associated with effective cough or in people with Persistent respiratory disease in which interference with ability to obvious the tracheobronchial tree of secretions would've a deleterious impact on the affected person’s respiratory operate.
It is very important that you comprehend the rules of your Opioid Analgesic REMS software to stop addiction, abuse, and misuse of codeine. This medication also needs to have a Medication Information. Read through and comply with these Directions cautiously. Go through it again each time you refill your prescription in the event that There exists new information. Inquire your doctor For those who have any inquiries.